TYPES
OF
HAZARD/
EXPOSURE |
ACUTE
HAZARDS/
CLINICAL SIGNS/
SYMPTOMS |
PREVENTION/
PERSONAL PROTECTIVE EQUIPMENT |
FIRST
AID/
FIRE FIGHTING |
FIRE |
N/A |
Avoid generating dust. |
Foam, dry chemical powder, BCF (where regulations
permit), carbon dioxide, water spray or fog - large fires only.
|
EXPLOSION |
N/A |
N/A
|
N/A |
ROUTE OF
EXPOSURE |
Synopsis: |
Extremely Toxic.
Abrin (and Ricin) cause toxicity by inhibition of protein
synthesis.
May possibly cause severe allergic reactions.
|
AVOID ALL CONTACT.
STRICT HYGIENE!
|
Seek medical attention immediately. |
Inhalation: |
Irritation.
(See Ingestion for other symptoms.) |
Pressure demand, self-contained breathing apparatus
(SCBA) (SCBA CBRN, if available) is recommended in response to non-routine
emergency situations.
Breath Response (pressure demand) HEPA PAPR.
See CDC/NIOSH
Interim Recommendations.
|
Fresh air, rest. Half-upright position. Perform
CPR if necessary.
Seek medical attention immediately. |
Skin: |
Potential for allergic skin reaction; redness,
blisters, pain.
May be absorbed! |
Tychem® BR or Responder® CSM protective clothing.
Eyes should be protected when possible.
|
Remove contaminated clothes. Rinse skin with
plenty of water or shower (and soap if available).
Seek medical attention immediately.
|
Eyes: |
Tearing, swelling of the eyelids, pain, redness,
corneal injury.
|
Goggles with respiratory protection or full face-piece
respirator
|
Immediately flush with large amounts of tepid
water for at least 15 minutes.
Seek medical attention immediately.
|
| Ingestion: |
Cardiovascular (heart and blood circulation) shock
from severe dehydration, life-threatening low blood pressure, fast
heart rate (tachycardia) and irregular heart rhythms (arrhythmias).
Central Nervous System (brain) - drowsiness, disorientation, hallucinations,
seizures, coma.
Gastrointestinal (stomach and intestines) - burning pain in the
mouth, abdominal pain, nausea, vomiting, diarrhea, bleeding and
swelling of the lining of the GI tract, liver cell damage and death.
Genitourinary (kidneys and urine) - blood in urine, low or no
urinary output, kidney cell damage and death.
Musculoskeletal - muscle weakness, tremors, and muscle spasm (tetany)
Eyes - dilated pupils and bleeding in the back of the eye (retinal
hemorrhage)
Skin - blue skin (cyanosis) and redness (flushing)
Symptoms delayed 1-3 days
May be fatal.
|
Do not eat, drink, or smoke during work. Wash hands
before eating. |
Rinse mouth. Do not induce vomiting. Use slurry of
activated charcoal. In the event of vomiting, lean patient forward
or place on left side (head-down position, if possible) to maintain
open airway and prevent aspiration. Early and aggressive IV fluid
and electrolyte replacement.
Seek medical attention immediately. |
|
OCCUPATIONAL EXPOSURE
LIMITS (OELs): |
OSHA PEL: N/A
NIOSH REL: N/A
ACGIH TLV: N/A
ChemWatch : Ceiling: 0.00006 mg/m3 (sensitizer)
NIOSH IDLH: N/A
|
SAMPLING AND ANALYTICAL METHODS: |
NIOSH: N/A
OSHA: N/A |
| |
DECONTAMINATION |
Patient/Victim:
Wash with soap and water. Work clothes should be laundered separately.
Launder contaminated clothing before re-use. Do not take clothing
home.
Equipment: N/A
Environment: Use dry clean up procedures and avoid
generating dust. ((See Spillage Disposal.)
|
SPILLAGE DISPOSAL |
Polyethylene or polypropylene container.
Keep containers securely sealed when not in use.
Store in a cool, dry, well-ventilated area and away from food stuff
containers.
|
PACKAGING
& LABELLING
|
UN#:
3172
(Guide 153) |
Proper Shipping Name: N/A
|
| Hazard Class: 6.1(a) |
| Packing Group: I |
NFPA 704 Signal:
Health - N/A
Flammability - N/A
Reactivity - N/A
Special - N/A |
| |
|
IMPORTANT
DATA |
PHYSICAL STATE; APPEARANCE:
Yellowish-white powder
PHYSICAL DANGERS:
Product is considered stable. Avoid contact with oxidizing agents.
CHEMICAL DANGERS:
Hazardous polymerization will not occur.
ROUTES OF EXPOSURE:
Can be absorbed by all routes of exposure.
INHALATION RISK:
Irritation, sensitization
EFFECTS OF SHORT-TERM EXPOSURE:
Severe vomiting and diarrhea may result in severe dehydration (hypovolaemic-shock)
and multisystem organ failure: effects on GI tract, kidney, liver,
and pancreas.
EFFECTS OF LONG-TERM OR REPEATED EXPOSURE:
Unknown. However, based on its similarity to ricin, abrin may cause
Allergic syndrome with congestion of nose and throat; itchy, watery
eyes; hives; tightness of the chest; and in severe cases - wheezing.
|
PHYSICAL
PROPERTIES |
Melting Point: N/A
|
| Boiling Point: decomposes [see NOTES] |
| Vapor Pressure (20°C): Negligible |
| Density (20°C): N/A |
| Volatility: Negligible |
| Specific gravity: N/A aqueous solubility(20°C):
Partly miscible |
| Aqueous solubility(25°C): 160
mg/L (sparingly soluble) |
| Soluble: NaCl solution with turbidity
estimated log Kow: N/A |
| Flashpoint: N/A |
Flammability: N/A |
ENVIRONMENTAL
DATA |
|
ACUTE EXPOSURE
GUIDELINES (AEGLs)
|
| |
10 min |
30 min |
1hr |
4 hr |
8 hr |
| AEGL 1 (discomfort, non-disabling) |
N/A |
N/A |
N/A |
N/A |
N/A |
| AEGL 2 (irreversible or other serious,
long-lasting effects or impaired ability to escape) |
N/A |
N/A |
N/A |
N/A |
N/A |
AEGL 3 (life-threatening effects or death)
|
N/A |
N/A |
N/A |
N/A |
N/A |
|
NOTES |
| Toxic proteins of
Abrin are resistant to digestive enzymes but are destroyed in cooking.
The toxic portion is heat stable to 140°F (60° C) for 30 minutes;
at 176° F (80° C) most of the toxicity is lost in 30 minutes.
EXTREMELY TOXIC - Lethal dose after oral consumption by humans is
approximately 0.005-0.007 mg/kg. |
| |
ADDITIONAL
INFORMATION |
Trade Names and Other Synonyms:
- jequirity bean
- phytotoxin (abrus precatorius seed)
- Indian licorice seed
- rosary pea
- jumble bead
- prayer bead
- precatory bean
- Mienie-Mienie
- Indian bead
- Seminole bead
- weather plant
- lucky bean
- love bean
- buddhist rosary bead
- lectin protein
|
| |
GLOSSARY OF ACRONYMS |
APR - Air-purifying
Respirator
CBRN - Chemical, Biological, Radiological, Nuclear
IDLH - Immediately Dangerous to Life and Health
REL - Recommended Exposure Limit
PEL - Permissible Exposure Limit
SCBA - Self-Contained Breathing Apparatus |
| |
IMPORTANT
NOTICE: |
ABRIN (ERC1393-62-0)
The user should verify compliance of the cards with the relevant STATE
or TERRITORY legislation before use. NIOSH, CDC 2003. |