NIOSH EMERGENCY RESPONSE CARD

 

BIOTOXIN

ABRIN

 

UN #: 3172 (Guide 153)

CAS #: 1393-62-0

RTECS #: AA5250000

Abrins
Agglutinin
Crab's Eyes
Indian licorice seed
Jumble bead
Prayer bead
Toxalbumin

Chemical Formula: N/A

Molecular weight: 63000-67000
 

TYPES OF
HAZARD/
EXPOSURE

ACUTE HAZARDS/
CLINICAL SIGNS/
SYMPTOMS

PREVENTION/
PERSONAL PROTECTIVE EQUIPMENT

FIRST AID/
FIRE FIGHTING

FIRE

N/A Avoid generating dust.

Foam, dry chemical powder, BCF (where regulations permit), carbon dioxide, water spray or fog - large fires only.

EXPLOSION

N/A N/A
 
N/A

ROUTE OF
EXPOSURE

Synopsis:

Extremely Toxic.

Abrin (and Ricin) cause toxicity by inhibition of protein synthesis.

May possibly cause severe allergic reactions.

AVOID ALL CONTACT.

STRICT HYGIENE!

Seek medical attention immediately.

Inhalation:

Irritation.

(See Ingestion for other symptoms.)

Pressure demand, self-contained breathing apparatus (SCBA) (SCBA CBRN, if available) is recommended in response to non-routine emergency situations.

Breath Response (pressure demand) HEPA PAPR.

See CDC/NIOSH Interim Recommendations.

Fresh air, rest. Half-upright position. Perform CPR if necessary.

Seek medical attention immediately.

Skin:

Potential for allergic skin reaction; redness, blisters, pain.

May be absorbed!

Tychem® BR or Responder® CSM protective clothing. Eyes should be protected when possible.

Remove contaminated clothes. Rinse skin with plenty of water or shower (and soap if available).

Seek medical attention immediately.

Eyes:

Tearing, swelling of the eyelids, pain, redness, corneal injury.

Goggles with respiratory protection or full face-piece respirator

Immediately flush with large amounts of tepid water for at least 15 minutes.

Seek medical attention immediately.

Ingestion:
  • Cardiovascular (heart and blood circulation) shock from severe dehydration, life-threatening low blood pressure, fast heart rate (tachycardia) and irregular heart rhythms (arrhythmias).
  • Central Nervous System (brain) - drowsiness, disorientation, hallucinations, seizures, coma.
  • Gastrointestinal (stomach and intestines) - burning pain in the mouth, abdominal pain, nausea, vomiting, diarrhea, bleeding and swelling of the lining of the GI tract, liver cell damage and death.
  • Genitourinary (kidneys and urine) - blood in urine, low or no urinary output, kidney cell damage and death.
  • Musculoskeletal - muscle weakness, tremors, and muscle spasm (tetany)
  • Eyes - dilated pupils and bleeding in the back of the eye (retinal hemorrhage)
  • Skin - blue skin (cyanosis) and redness (flushing)

    Symptoms delayed 1-3 days

    May be fatal.
  • Do not eat, drink, or smoke during work. Wash hands before eating. Rinse mouth. Do not induce vomiting. Use slurry of activated charcoal. In the event of vomiting, lean patient forward or place on left side (head-down position, if possible) to maintain open airway and prevent aspiration. Early and aggressive IV fluid and electrolyte replacement.

    Seek medical attention immediately.


    OCCUPATIONAL EXPOSURE LIMITS (OELs):

    OSHA PEL: N/A
    NIOSH REL: N/A
    ACGIH TLV: N/A
    ChemWatch : Ceiling: 0.00006 mg/m3 (sensitizer)
    NIOSH IDLH: N/A

    SAMPLING AND ANALYTICAL METHODS:

    NIOSH: N/A

    OSHA: N/A
     

    DECONTAMINATION

    Patient/Victim: Wash with soap and water. Work clothes should be laundered separately. Launder contaminated clothing before re-use. Do not take clothing home.

    Equipment: N/A

    Environment: Use dry clean up procedures and avoid generating dust. ((See Spillage Disposal.)

    SPILLAGE DISPOSAL

    Polyethylene or polypropylene container.

    Keep containers securely sealed when not in use.

    Store in a cool, dry, well-ventilated area and away from food stuff containers.

    PACKAGING & LABELLING

     

    UN#: 3172 (Guide 153)

    Proper Shipping Name: N/A

    Hazard Class: 6.1(a)
    Packing Group: I
      NFPA 704 Signal:

      Health - N/A
      Flammability - N/A
      Reactivity - N/A
      Special - N/A
       

    IMPORTANT DATA

    PHYSICAL STATE; APPEARANCE:
    Yellowish-white powder

    PHYSICAL DANGERS:
    Product is considered stable. Avoid contact with oxidizing agents.

    CHEMICAL DANGERS:
    Hazardous polymerization will not occur.

    ROUTES OF EXPOSURE:
    Can be absorbed by all routes of exposure.

    INHALATION RISK:
    Irritation, sensitization

    EFFECTS OF SHORT-TERM EXPOSURE:
    Severe vomiting and diarrhea may result in severe dehydration (hypovolaemic-shock) and multisystem organ failure: effects on GI tract, kidney, liver, and pancreas.

    EFFECTS OF LONG-TERM OR REPEATED EXPOSURE:
    Unknown. However, based on its similarity to ricin, abrin may cause Allergic syndrome with congestion of nose and throat; itchy, watery eyes; hives; tightness of the chest; and in severe cases - wheezing.

    PHYSICAL
    PROPERTIES

    Melting Point: N/A

    Boiling Point: decomposes [see NOTES]
    Vapor Pressure (20°C): Negligible
    Density (20°C): N/A
    Volatility: Negligible
    Specific gravity: N/A aqueous solubility(20°C): Partly miscible
    Aqueous solubility(25°C): 160 mg/L (sparingly soluble)
    Soluble: NaCl solution with turbidity estimated log Kow: N/A
    Flashpoint: N/A

    Flammability: N/A

    ENVIRONMENTAL
    DATA

     

    ACUTE EXPOSURE
    GUIDELINES (AEGLs)

      10 min 30 min 1hr 4 hr 8 hr
    AEGL 1 (discomfort, non-disabling) N/A N/A N/A N/A N/A
    AEGL 2 (irreversible or other serious, long-lasting effects or impaired ability to escape) N/A N/A N/A N/A N/A
    AEGL 3 (life-threatening effects or death)
    N/A N/A N/A N/A N/A

    NOTES

    Toxic proteins of Abrin are resistant to digestive enzymes but are destroyed in cooking. The toxic portion is heat stable to 140°F (60° C) for 30 minutes; at 176° F (80° C) most of the toxicity is lost in 30 minutes. EXTREMELY TOXIC - Lethal dose after oral consumption by humans is approximately 0.005-0.007 mg/kg.
     

    ADDITIONAL
    INFORMATION

    Trade Names and Other Synonyms:

    • jequirity bean
    • phytotoxin (abrus precatorius seed)
    • Indian licorice seed
    • rosary pea
    • jumble bead
    • prayer bead
    • precatory bean
    • Mienie-Mienie
    • Indian bead
    • Seminole bead
    • weather plant
    • lucky bean
    • love bean
    • buddhist rosary bead
    • lectin protein
     

    GLOSSARY OF ACRONYMS

    APR - Air-purifying Respirator
    CBRN -
    Chemical, Biological, Radiological, Nuclear
    IDLH -
    Immediately Dangerous to Life and Health
    REL -
    Recommended Exposure Limit
    PEL -
    Permissible Exposure Limit
    SCBA - Self-Contained Breathing Apparatus

     

    IMPORTANT
    NOTICE:

    ABRIN (ERC1393-62-0) The user should verify compliance of the cards with the relevant STATE or TERRITORY legislation before use. NIOSH, CDC 2003.