The Registry of Toxic Effects of Chemical Substances (RTECS)

The Registry of Toxic Effects of Chemical Substances

Chlorine fluoride

RTECS #: FO2800000

CAS #: 7790-91-2

UPDATE: November 2004 MW: 92.45 MF: ClF₃

NOTE:

TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.

TABLE OF CONTENTS:

SYNONYMS:

SKIN AND EYE IRRITATION DATA:

ACUTE TOXICITY DATA:

OTHER MULTIPLE DOSE DATA:

REVIEWS:

STANDARDS AND REGULATIONS:

NIOSH DOCUMENTATION AND SURVEILLANCE:

STATUS IN FEDERAL AGENCIES:

REFERENCES:

SYNONYMS:

Chlorine trifluoride

Chlorine trifluoride (ACGIH:OSHA)

Chlorotrifluoride

Trifluorure de chlore (French)

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
eye
dog 21 ppm/12 hour- intermittent N/R AMIHAB 12,515,1955
eye
rat 21 ppm/12 hour- intermittent N/R AMIHAB 12,515,1955

MUTATION DATA AND REFERENCES:
SYSTEM TEST ROUTE/
ORGANISM/
TISSUE DOSE REFERENCE
N/R N/R N/R N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
inhalation
dog lowest published toxic concentration: 1,800 mg/m³/2 minute Olfaction: Other olfaction effects

Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Cough VCVN5* -,386,1989
inhalation
dog lowest published toxic concentration: 1,800 mg/m³/5 minute Eye: Lacrimation

Eye: Corneal damage VCVN5* -,386,1989
inhalation
dog lowest published lethal concentration: 360 mg/m³/4 hour N/R VCVN5* -,386,1989
inhalation
human lowest published lethal concentration: 50 ppm N/R 34ZIAG -,651,1966
inhalation
mammal (species unspecified) lowest published toxic concentration: 80 mg/m³/10 minute Lung, Thorax, or Respiration: Cough VCVN5* -,386,1989
inhalation
monkey lethal concentration (50 percent kill): 230 ppm/1 hour Behavioral: Muscle weakness

Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Lung, Thorax, or Respiration: Cyanosis AMRL TR-70-77,1970
inhalation
mouse lethal concentration (50 percent kill): 178 ppm/1 hour Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Lung, Thorax, or Respiration: Cyanosis AMRL TR-70-77,1970
inhalation
rat lethal concentration (50 percent kill): 299 ppm/1 hour N/R TXAPA9 42,417,1977
inhalation
rat lowest published lethal concentration: 3,000 mg/m³/15 minute N/R VCVN5* -,385,1989
inhalation
rat lowest published lethal concentration: 1,500 mg/m³/35 minute N/R VCVN5* -,386,1989
inhalation
rabbit lowest published toxic concentration: 1,800 mg/m³/2 minute Olfaction: Other olfaction effects

Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Cough VCVN5* -,386,1989
inhalation
rabbit lowest published toxic concentration: 1,800 mg/m³/5 minute Eye: Lacrimation

Eye: Corneal damage VCVN5* -,386,1989
inhalation
rabbit lowest published lethal concentration: 360 mg/m³/4 hour N/R VCVN5* -,386,1989

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
inhalation
dog lowest published toxic concentration: 5,150 ppb/6 hour/6 week- intermittent Eye: Corneal damage

Lung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field AMIHAB 12,515,1955
inhalation
dog lowest published toxic concentration: 1,170 ppb/6 hour/26 week- intermittent Eye: Lacrimation

Lung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field AMIHAB 13,340,1956
inhalation
dog lowest published toxic concentration: 20 mg/m³/6 hour/6 week- intermittent Lung, Thorax, or Respiration: Emphysema

Lung, Thorax, or Respiration: Acute pulmonary edema

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field VCVN5* -,386,1989
inhalation
mammal (species unspecified) lowest published toxic concentration: 2 mg/m³/17 week- intermittent Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Other changes

Musculoskeletal: Other changes STGNBT -,239,1999
inhalation
mammal (species unspecified) lowest published toxic concentration: 4 mg/m³/6 hour/26 week- intermittent Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Cough VCVN5* -,386,1989
inhalation
mammal (species unspecified) lowest published toxic concentration: 4 mg/m³/6 hour/8 week- intermittent Lung, Thorax, or Respiration: Other changes VCVN5* -,386,1989
inhalation
rat lowest published toxic concentration: 5,150 ppb/6 hour/6 week- intermittent Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Gastrointestinal: Changes in structure or function of salivary glands

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field AMIHAB 12,515,1955
inhalation
rat lowest published toxic concentration: 1,170 ppb/6 hour/26 week- intermittent Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field AMIHAB 13,340,1956
inhalation
rat lowest published toxic concentration: 20 mg/m³/6 hour/6 week- intermittent Lung, Thorax, or Respiration: Emphysema

Lung, Thorax, or Respiration: Acute pulmonary edema

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field VCVN5* -,386,1989

REVIEWS:
ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value ceiling concentration 0.1 ppm DTLVS* TLV/BEI,2003
TOXICOLOGY REVIEW
TXAPA9 27,527,1974

STANDARDS AND REGULATIONS:
ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD air-ceiling concentration 0.1 ppm (0.4 mg/m³) DTLWS* 3,11,1972
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) ceiling concentration 0.1 ppm (0.4 mg/m³) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) ceiling concentration 0.1 ppm (0.4 mg/m³) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) ceiling concentration 0.1 ppm (0.4 mg/m³) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) ceiling concentration 0.1 ppm (0.4 mg/m³) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.1 ppm (0.4 mg/m³), JAN1993
Occupational Exposure Limit - AUSTRIA MAK 0.1 ppm (0.4 mg/m³), JAN1999
Occupational Exposure Limit - BELGIUM short term exposure limit 0.1 ppm (0.38 mg/m³), JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 0.1 ppm (0.4 mg/m³), JAN1999
Occupational Exposure Limit - FINLAND short term exposure limit 0.1 ppm (0.4 mg/m³), JAN1999
Occupational Exposure Limit - FRANCE VLE 0.4 mg/m³, JAN1999
Occupational Exposure Limit - GERMANY MAK 0.1 ppm (0.4 mg/m³), JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC- continuous 0.4 mg/m³, 2003
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.1 ppm (0.4 mg/m³), JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 1 mg(HF)/m³, MAC(short term exposure limit) 3 mg(HF)/m³, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 0.1 ppm (0.4 mg/m³), KZG- week 0.2 ppm (0.8 mg/m³), JAN1999
Occupational Exposure Limit - THAILAND time-weighted average 0.1 ppm (0.4 mg/m³), JAN1993
Occupational Exposure Limit - UNITED KINGDOM short term exposure limit 0.1 ppm (0.38 mg/m³), SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

ceiling concentration 0.1 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
ceiling concentration 0.1 ppm

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CHLORINE TRIFLUORIDE-air ceiling concentration 0.1 ppm NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 18050;
Number of Industries 1;
Total Number of Facilities 11;
Number of Occupations 3;
Total Number of Employees Exposed 357

STATUS IN FEDERAL AGENCIES:
ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY

REFERENCES:
CODEN
REFERENCE

34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU.
AMRL** Aerospace Medical Research Laboratory Report. (Aerospace Technical Div., Air Force Systems Command, Wright-Patterson Air Force Base, OH 45433)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
DTLWS* "Documentation of the Threshold Limit Values for Substances in Workroom Air," Supplements. For publisher information, see 85INA8.
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
STGNBT "Spravochnik po Toksikologii i Gigienicheskim Normativam (PDK) Potentsial'no Opasnykh Khimicheskikh Veshchestv" Kushneva, V.S., and R.B. Gorshkova, eds. 46, Zhivopisnaya St., 123182, Moscow, Russia, IzdAT 1999
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVN5* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov V-VII groopp" (Hazardous substances. Inornanic substances containing V-VII group elements), Bandman A.L. et al., Chimia, 1989.

RTECS Compound Description:
Human Data
Primary Irritant