The Registry of Toxic Effects of Chemical Substances

Butyraldehyde


RTECS #: ES2275000

CAS #: 123-72-8

UPDATE: February 2003 MW: 72.12 MF: C4H8O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Aldehyde butyrique (French)
  2. Aldeide butirrica (Italian)
  3. Butal
  4. Butaldehyde
  5. Butalyde
  6. Butanal
  7. n - Butanal (Czech)
  8. Butanaldehyde
  1. Butyl aldehyde
  2. n - Butyl aldehyde
  3. Butyral
  4. Butyraldehyd (German)
  5. Butyric aldehyde
  6. n - Butyraldehyde
  7. NCI - C56291


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		20 mg/24 hour moderate 85JCAE -,270,1986
skin
rabbit 		410 mg open irritation test mild UCDS** 7/20/1965


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA damage mammal (species unspecified) lymphocyte 100 mmol/L MUREAV 283,131,1992
unscheduled DNA synthesis rat liver 30 mmol/L MUREAV 323,121,1994
mutation in mammalian somatic cells hamster lung 3 mmol/L MUTAEX 4,277,1989
sister chromatid exchange hamster ovary 9 mg/L EMMUEG 10(Suppl 10),1,1987
sperm morphology intraperitoneal
mouse 		30 mg/kg MUREAV 39,317,1977
sperm morphology oral
mouse 		15 gm/kg/50 day MUREAV 39,317,1977


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
cat 		lowest published toxic concentration: 5,000 mg/m3 Gastrointestinal: Changes in structure or function of salivary glands VCVGK* -,373,1984
inhalation
human 		lowest published toxic concentration: 13 mg/m3 Eye: Conjunctiva irritation VCVGK* -,373,1984
inhalation
human 		lowest published toxic concentration: 0.75 mg/m3 Brain and Coverings: Other degenerative changes VCVGK* -,373,1984
inhalation
mammal (species unspecified) 		lethal concentration (50 percent kill): 38 gm/m3 N/R GISAAA 51(5),61,1986
inhalation
mouse 		lethal concentration (50 percent kill): 44,610 mg/m3/2 hour N/R 85GMAT -,30,1982
inhalation
mouse 		lethal concentration (50 percent kill): 36,000 mg/m3/2 hour Eye: Conjunctiva irritation

Behavioral: Ataxia

Lung, Thorax, or Respiration: Acute pulmonary edema 		VCVGK* -,373,1984
inhalation
rat 		lowest published lethal concentration: 8,000 ppm/4 hour N/R NTIS** OTS0516688
inhalation
rat 		lethal concentration (50 percent kill): 6,400 ppm/4 hour Eye: Conjunctiva irritation

Behavioral: Ataxia

Lung, Thorax, or Respiration: Acute pulmonary edema 		VCVGK* -,373,1984
inhalation
rat 		lowest published toxic concentration: 600 ppm/10 minute Lung, Thorax, or Respiration: Respiratory depression VCVGK* -,373,1984
inhalation
rabbit 		lowest published toxic concentration: 200 mg/m3/40 minute Lung, Thorax, or Respiration: Dyspnea VCVGK* -,373,1984
intraperitoneal
mouse 		lethal dose (50 percent kill): 1,140 mg/kg N/R FCTXAV 17,731,1979
intraperitoneal
rat 		lethal dose (50 percent kill): 800 mg/kg N/R FCTXAV 17,731,1979
oral
rat 		lethal dose (50 percent kill): 2,490 mg/kg N/R NTIS** OTS0516688
oral
rat 		lethal dose (50 percent kill): 5,890 mg/kg Eye: Conjunctiva irritation

Behavioral: Ataxia

Lung, Thorax, or Respiration: Acute pulmonary edema 		VCVGK* -,373,1984
subcutaneous
mouse 		lethal dose (50 percent kill): 2,700 mg/kg Behavioral: General anesthetic

Kidney, Ureter, and Bladder: Hematuria 		APTOA6 6,299,1950
subcutaneous
rat 		lethal dose (50 percent kill): 10 gm/kg Behavioral: General anesthetic APTOA6 6,299,1950
skin
rabbit 		lethal dose (50 percent kill): 3,560 µL/kg N/R UCDS** 7/20/1965


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
dog 		lowest published toxic concentration: 3,100 ppm/6 hour/2 week- intermittent Eye: Lacrimation

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Changes in structure or function of salivary glands 		NTIS** OTS0570659
inhalation
dog 		lowest published toxic concentration: 2,000 ppm/6 hour/14 week- intermittent Olfaction: Other olfaction effects NTIS** OTS0538653
inhalation
guinea pig 		lowest published toxic concentration: 3,100 ppm/6 hour/2 week- intermittent Eye: Lacrimation

Lung, Thorax, or Respiration: Dyspnea

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTIS** OTS0570659
inhalation
mouse 		lowest published toxic concentration: 6,400 ppm/6 hour/2 week- intermittent Eye: Other eye effects

Lung, Thorax, or Respiration: Dyspnea

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		NTIS** OTS0570659
inhalation
rat 		lowest published toxic concentration: 3,100 ppm/6 hour/2 week- intermittent Lung, Thorax, or Respiration: Dyspnea

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTIS** OTS0570659
inhalation
rat 		lowest published toxic concentration: 125 ppm/6 hour/13 week- intermittent Olfaction: Other olfaction effects

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) 		NTIS** OTS0538653
inhalation
rat 		lowest published toxic concentration: 125 ppm/6 hour/13 week- intermittent Olfaction: Other olfaction effects VCVGK* -,373,1994
inhalation
rat 		lowest published toxic concentration: 50 mg/m3/110 day- intermittent Lung, Thorax, or Respiration: Emphysema

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes 		VCVGK* -,373,1994
inhalation
rat 		lowest published toxic concentration: 0.5 mg/m3/120 day- intermittent Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases 		VCVGK* -,373,1994
inhalation
rabbit 		lowest published toxic concentration: 3,100 ppm/6 hour/2 week- intermittent Eye: Lacrimation

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Changes in structure or function of salivary glands 		NTIS** OTS0570659
inhalation
rabbit 		lowest published toxic concentration: 50 mg/m3/110 day- intermittent Lung, Thorax, or Respiration: Emphysema

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes 		VCVGK* -,373,1994
oral
mouse 		lowest published toxic dose: 78 gm/kg/90 day- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTIS** OTS0516688
oral
mouse 		lowest published toxic dose: 15,000 mg/kg/12 day- intermittent Lung, Thorax, or Respiration: Changes in lung weight

Gastrointestinal: Ulceration or bleeding from stomach 		VCVGK* -,373,1994
oral
rat 		lowest published toxic dose: 39 gm/kg/90 day- intermittent Lung, Thorax, or Respiration: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		NTIS** OTS0516688
oral
rat 		lowest published toxic dose: 15,000 mg/kg/12 day- intermittent Lung, Thorax, or Respiration: Changes in lung weight

Gastrointestinal: Ulceration or bleeding from stomach 		VCVGK* -,373,1994


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
EVHPAZ 11,163,1975


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - RUSSIA short term exposure limit 5 mg/m3, Skin, JAN1993


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M0281;
Number of Industries 3;
Total Number of Facilities 91;
Number of Occupations 9;
Total Number of Employees Exposed 1,258
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M0281;
Number of Industries 2;
Total Number of Facilities 38;
Number of Occupations 6;
Total Number of Employees Exposed 5,392;
Total Number of Female Employees Exposed 950


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH CURRENT INTELLIGENCE BULLETIN #55, September 1991
NIOSH Analytical Method, 1994: Aldehydes, screening, 2539


REFERENCES:

CODEN
REFERENCE
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.




RTECS Compound Description:
   Mutagen
   Human Data
   Primary Irritant