The Registry of Toxic Effects of Chemical Substances

Acetyl chloride


RTECS #: AO6390000

CAS #: 75-36-5

UPDATE: September 1998 MW: 78.50 MF: C2H3ClO


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. NIOSH DOCUMENTATION AND SURVEILLANCE:
  5. STATUS IN FEDERAL AGENCIES:
  6. REFERENCES:

SYNONYMS:

  1. Acetic acid, chloride
  2. Acetic chloride
  1. Ethanoyl chloride
  2. RCRA waste number U006


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
gene conversion and mitotic recombination oral
Drosophila melanogaster 		62,500 µmol/L CRNGDP 17,1083,1996


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
human 		lowest published toxic concentration: 2 ppm/1 minute Olfaction: Other olfaction effects

Lung, Thorax, or Respiration: Other changes 		TGNCDL 2,28,1961
oral
rat 		lethal dose (50 percent kill): 910 mg/kg Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: Excitement

Lung, Thorax, or Respiration: Other changes 		GTPZAB 32(3),48,1988


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 81687;
Number of Industries 4;
Total Number of Facilities 96;
Number of Occupations 7;
Total Number of Employees Exposed 931
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 81687;
Number of Industries 3;
Total Number of Facilities 40;
Number of Occupations 5;
Total Number of Employees Exposed 2,534;
Total Number of Female Employees Exposed 575


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
On EPA IRIS database


REFERENCES:

CODEN
REFERENCE
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
TGNCDL "Handbook of Organic Industrial Solvents," 2nd ed., Chicago, National Assoc. of Mutual Casualty Companies, 1961




RTECS Compound Description:
   Mutagen
   Human Data