The Registry of Toxic Effects of Chemical Substances

Acetic acid, chloro -


RTECS #: AF8575000

CAS #: 79-11-8

UPDATE: November 2003 MW: 94.50 MF: C2H3ClO2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Kyselina chloroctova (Czech)
  2. NCI - C60231
  3. Acide chloracetique (French)
  4. Acide monochloracetique (French)
  5. Acidomonocloroacetico (Italian)
  6. Chloracetic acid
  7. Chloroacetic acid
  8. alpha - Chloroacetic acid
  1. Chloroethanoic acid
  2. MCA
  3. Monochloorazijnzuur (Dutch)
  4. Monochloracetic acid
  5. Monochloressigsaeure (German)
  6. Monochloroacetic acid
  7. Monochloroethanoic acid


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA damage hamster ovary 0.411 mmol/L/4 hour EMMUEG 40,134,2002
mutation in microorganisms mouse lymphocyte 548 mg/L (+enzymatic activation step) MUREAV 97,49,1982
mutation in mammalian somatic cells mouse lymphocyte 400 mg/L ENMUDM 9,143,1987
sister chromatid exchange hamster ovary 160 mg/L EMMUEG 10(Suppl 10),1,1987
specific locus test mouse other cell types 5 mg/L/4 hour (+enzymatic activation step) EMMUEG 38,69,2001


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
subcutaneous
mouse 		lowest published toxic dose: 100 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors 		NTIS** PB223-159
subcutaneous
mouse 		toxic dose : 1,300 mg/kg/65 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Tumorigenic: Tumors at site of application 		JNCIAM 53,695,1974


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration (50 percent kill): 180 mg/m3 N/R GTPZAB 18(9),32,1974
intraperitoneal
rat 		lethal dose (50 percent kill): 16,600 µg/kg N/R RPTOAN 41,113,1978
oral
rat 		lethal dose (50 percent kill): 55 mg/kg N/R GTPZAB 18(9),32,1974
subcutaneous
mouse 		lethal dose (50 percent kill): 250 mg/kg N/R AIPTAK 116,154,1958
subcutaneous
rat 		lethal dose (50 percent kill): 5 mg/kg N/R TXAPA9 22,303,1972


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
guinea pig 		lowest published toxic concentration: 20,800 µg/m3/17 week- intermittent Kidney, Ureter, and Bladder: Other changes

Blood: Pigmented or nucleated red blood cells 		GTPZAB 18(9),32,1974
inhalation
rat 		lowest published toxic concentration: 20,800 µg/m3/17 week- intermittent Kidney, Ureter, and Bladder: Other changes

Blood: Pigmented or nucleated red blood cells 		GTPZAB 18(9),32,1974
oral
mouse 		lowest published toxic dose: 13 gm/kg/13 week- intermittent Liver: Other changes

Liver: Changes in liver weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		NTPTR* NTP-TR-396,1992
oral
mouse 		lowest published toxic dose: 3,840 mg/kg/16 day- intermittent Eye: Lacrimation

Behavioral: Ataxia

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		NTPTR* NTP-TR-396,1992
oral
mouse 		lowest published toxic dose: 25,750 mg/kg/103 week- intermittent Blood: Lymphoma including Hodgkin's disease

Tumorigenic: Active as anti-cancer agent 		NTIS** PB92-189372
oral
rat 		lowest published toxic dose: 9,750 mg/kg/13 week- intermittent Cardiac: Other changes

Blood: Changes in erythrocyte (RBC) count

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		NTPTR* NTP-TR-396,1992


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
APTOA6 11,13,1955


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - POLAND MAC(time-weighted average) 2 mg/m3, MAC(short term exposure limit) 4 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 1 mg/m3, JAN1993
Occupational Exposure Limit - SWEDEN time-weighted average 1 ppm (4 mg/m3), short term exposure limit 2 ppm (8 mg/m3), Skin, JAN1999
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.3 ppm (1.2 mg/m3), Skin, SEP2000


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 18070;
Number of Industries 9;
Total Number of Facilities 1,196;
Number of Occupations 14;
Total Number of Employees Exposed 4,726
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 18070;
Number of Industries 12;
Total Number of Facilities 265;
Number of Occupations 20;
Total Number of Employees Exposed 10,912;
Total Number of Female Employees Exposed 1,723


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Chloroacetic acid, 2008
NCI Carcinogenesis Studies (gavage);no evidence:mouse,rat


REFERENCES:

CODEN
REFERENCE
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898-
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
RPTOAN Russian Pharmacology and Toxicology (English Translation). Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey, UK) V.30- 1967-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-




RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen